Trifluoroacetic acid → HCID 86692460、化合物
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:18]#[N:19])[CH2:17][CH2:16][C:11]3(OCC[O:12]3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.FC(F)(F)C(O)=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:18]#[N:19])[CH2:9][CH2:10][C:11](=[O:12])[CH2:16][CH2:17]2)=[N:6][CH:7]=1参加物
3
実験手順
To 8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile (3.4 g) described in Reference Example 82 was added trifluoroacetic acid (4.1 ml) at room temperature, and stirred at the same temperature for 22 hours. After completion of the reaction, the solvent and trifluoroacetic acid were evaporated. The obtained residue was purified with silica gel column chromatography (n-hexane:ethyl acetate) to give 1-(5-bromopyridin-2-yl)-4-oxocyclohexanecarbonitrile (2.78 g) as a white solid.
後処理
- customAfter completion of the reaction
- customthe solvent and trifluoroacetic acid were evaporated
- customThe obtained residue was purified with silica gel column chromatography (n-hexane:ethyl acetate)
出典と根拠
- ORDレコード
- ord-02ca3153db0340a9b9392d8df166cde7
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09150555B2
反応ノート
読み込み中…