Water → N-(6-chloro-5-cyanopyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide

HRID 1748666

反応式

HRID 1748666 の反応式
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][N:8]=2)[N:5]=[CH:4][C:3]=1[C:17](Cl)=[O:18].[NH2:20][C:21]1[CH:22]=[C:23]([C:28]#[N:29])[C:24]([Cl:27])=[N:25][CH:26]=1.O>N1C=CC=CC=1>[Cl:27][C:24]1[N:25]=[CH:26][C:21]([NH:20][C:17]([C:3]2[CH:4]=[N:5][N:6]([C:7]3[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][N:8]=3)[C:2]=2[CH3:1])=[O:18])=[CH:22][C:23]=1[C:28]#[N:29]

参加物

5

反応物 3

HCID 962WaterHCID 204962095-Amino-2-chloropyridine-3-carbonitrileHCID 897349975-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxylic acid chloride

生成物 1

HCID 86692611N-(6-chloro-5-cyanopyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide収率 195.8%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

5-Methyl-1-(5-(trifluoro methyl)pyridin-2-yl)-1H-pyrazole-4-carboxylic acid chloride (200 mg) and 5-amino-2-chloro-3-cyanopyridine (228 mg) were dissolved in pyridine (10 ml) and stirred at room temperature. After completion of the reaction, water was added to the reaction solution, the precipitated solid was collected by filtration and dried under heating and blow to give N-(6-chloro-5-cyanopyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (550 mg) as a light brown solid.

後処理

  1. additionwas added to the reaction solution
  2. filtrationthe precipitated solid was collected by filtration
  3. customdried
  4. temperatureunder heating

出典と根拠

ORDレコード
ord-79ace4301b51486bb49e09edddddf152
出典データセット
uspto-grants-2015_10
特許番号
US09150555B2

関連ノート

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