Ethyl Lactate → HCID 346572、化合物
反応式
[C:1]([O:6]CC)(=O)[CH:2]([CH3:4])[OH:3].[NH2:9][C:10]([CH3:14])([CH3:13])[CH2:11][OH:12]>C(O)C>[C:1]([NH:9][C:10]([CH3:14])([CH3:13])[CH2:11][OH:12])(=[O:6])[CH:2]([CH3:4])[OH:3]参加物
4
反応条件
- 温度
- 112.5 °C
実験手順
15 g of ethyl lactate and 10 g of 2-amino-2-methyl-1-propanol were mixed and subsequently heated to 110-115° C. for 3.5 hours. During the reaction, the ethanol formed was distilled off. After the reaction, the excess of ethyl lactate was removed by vacuum distillation (bottom temperature: 160° C., 7 mbar), using a vigreux column. 15.5 g of residual brown viscous liquid was collected, which was confirmed to be pure N-lactoyl 2-amino-2-methylpropanol by NMR analysis.
後処理
- customDuring the reaction
- distillationwas distilled off
- customAfter the reaction
- customthe excess of ethyl lactate was removed by vacuum distillation (bottom temperature: 160° C., 7 mbar)
- custom15.5 g of residual brown viscous liquid was collected
出典と根拠
- ORDレコード
- ord-5ea3950e5bf94a078808b5427f690440
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09155329B2
反応ノート
読み込み中…