p-Bromobenzenesulfonyl chloride → 4-bromo-N-(1,5-dimethyl-1H-pyrazol-4-yl)benzenesulfonamide

HRID 1749358

反応式

HRID 1749358 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:12][C:13]1[CH:14]=[N:15][N:16]([CH3:19])[C:17]=1[CH3:18]>N1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:12][C:13]2[CH:14]=[N:15][N:16]([CH3:19])[C:17]=2[CH3:18])(=[O:10])=[O:9])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 5738131,5-dimethyl-1H-pyrazol-4-amine

生成物 1

HCID 173768134-bromo-N-(1,5-dimethyl-1H-pyrazol-4-yl)benzenesulfonamide収率 71%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Prepared from 4-bromobenzenesulfonyl chloride (0.396 g, 1.55 mmol) and 4-amino-1,5-dimethyl-1H-pyrazole (0.172 g, 1.55 mmol) in pyridine (3 ml) according to the method of intermediate 1, to give the title compound as a yellow solid (0.362 g, 1.10 mmol, 71%). 5H (D-6 DMSO, 300K) 9.43 (1H, s), 7.80 (2H, d J 8.7 Hz), 7.58 (2H, d J 8.7 Hz), 3.63 (3H, s), 1.89 (3H, s). m/z (ES+, 70V) 332.0 (MH+).

出典と根拠

ORDレコード
ord-15e62489a77346b59743f3115252139d
出典データセット
uspto-grants-2015_10
特許番号
US09156811B2

関連ノート

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