1,5-dimethyl-1H-pyrazol-4-amine → 4-Bromo-2,6-dichloro-N-(1,5-dimethyl-1H-pyrazol-4-yl)-benzenesulfonamide

HRID 1749359

反応式

HRID 1749359 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([S:9](Cl)(=[O:11])=[O:10])=[C:4]([Cl:13])[CH:3]=1.[NH2:14][C:15]1[CH:16]=[N:17][N:18]([CH3:21])[C:19]=1[CH3:20]>N1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([S:9]([NH:14][C:15]2[CH:16]=[N:17][N:18]([CH3:21])[C:19]=2[CH3:20])(=[O:11])=[O:10])=[C:4]([Cl:13])[CH:3]=1

参加物

4

反応物 2

HCID 5738131,5-dimethyl-1H-pyrazol-4-amineHCID 27374664-Bromo-2,6-dichlorobenzene-1-sulfonyl chloride

生成物 1

HCID 585614054-Bromo-2,6-dichloro-N-(1,5-dimethyl-1H-pyrazol-4-yl)-benzenesulfonamide収率 64.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Prepared from 4-bromo-2,6-dichlorobenzenesulfonyl chloride (500 mg, 1.54 mmol) and 4-amino-1,5-dimethyl-1H-pyrazole (172 mg, 1.55 mmol) in pyridine (3 ml) according to the method of intermediate 1, to give the title compound as a cream solid (392 mg, 0.99 mmol, 64%). δH (D-6 DMSO, 300K) 9.91 (1H, s), 7.97 (2H, s), 3.64 (3H, s), 2.04 (3H, s). m/z (ES+, 70V) 399.9 (MH+).

出典と根拠

ORDレコード
ord-a95dfe19bb7846d89faa480e860fd947
出典データセット
uspto-grants-2015_10
特許番号
US09156811B2

関連ノート

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