Trifluoroacetic acid → 3-(2-Aminoethyl)-5-chloropyridine 1-oxide

HRID 1749470ノート

反応式

HRID 1749470 の反応式
C(OC([NH:8][CH2:9][CH2:10][C:11]1[CH:12]=[N+:13]([O-:18])[CH:14]=[C:15]([Cl:17])[CH:16]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[N+:13]([O-:18])[CH:14]=[C:15]([Cl:17])[CH:16]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 1181621543-(2-((tert-Butoxycarbonyl)amino)ethyl)-5-chloropyridine 1-oxide

生成物 1

HCID 1181621313-(2-Aminoethyl)-5-chloropyridine 1-oxide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-(2-((tert-butoxycarbonyl)amino)ethyl)-5-chloropyridine 1-oxide (90 mg, crude) in DCM (3 mL) was added TFA (1.5 mL) at 0° C. The resulting reaction mixture was stirred at room temperature for 1.5 h. The reaction mixture was concentrated to afford the crude title product, which was used directly in the next step without further purification (80 mg, crude). MS (ESI) m/z 173.1 [M+H]+.

後処理

  1. customThe resulting reaction mixture
  2. concentrationThe reaction mixture was concentrated

出典と根拠

ORDレコード
ord-dbeae91f70fa424f9520f5e46384c33f
出典データセット
uspto-grants-2015_10
特許番号
US09156798B2

反応ノート

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