Trifluoroacetic acid → 3-Amino-1-methylcyclohexan-1-ol
反応式
[OH:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([NH:8]C(=O)OC(C)(C)C)[CH2:3]1.[C:16](O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][CH:4]1[CH2:5][CH2:6][CH2:7][C:2]([CH3:16])([OH:1])[CH2:3]1参加物
4
実験手順
To a solution of crude tert-butyl (3-hydroxycyclohexyl)carbamate (4.0 g, crude) in DCM (40 mL) was added TFA (20 mL) under cooling in an ice bath. The resulting reaction mixture was stirred at room temperature for 2 h. The mixture was concentrated to give a crude product (3.0 g, crude), which was used in the next step without further purification. MS (ESI) m/z 130.1 [M+H]+.
後処理
- temperatureunder cooling in an ice bath
- customThe resulting reaction mixture
- concentrationThe mixture was concentrated
出典と根拠
- ORDレコード
- ord-4dbb77d86cb94a1f916a1ed0a16741c6
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09156798B2
反応ノート
読み込み中…