Trifluoroacetic acid → 1-(2-Amino-ethyl)-3-methyl-1,3-dihydro-benzoimidazol-2-one
反応式
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]([CH2:11][CH2:12][NH:13]C(=O)OC(C)(C)C)[C:3]1=[O:21].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:13][CH2:12][CH2:11][N:4]1[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:2]([CH3:1])[C:3]1=[O:21]参加物
4
実験手順
To a solution of tert-butyl (2-(3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)ethyl)carbamate (100 mg, 0.345 mmol) in DCM (3 mL) was added TFA (1.5 mL) at 0° C. to 5° C. The resulting reaction mixture was stirred at room temperature for 2 h. The reaction mixture was concentrated to give the crude product, which was used in the next step without further purification (140 mg crude). MS (ESI) m/z 192.1 [M+H]+.
後処理
- customThe resulting reaction mixture
- concentrationThe reaction mixture was concentrated
出典と根拠
- ORDレコード
- ord-eb1a1ceb073248e6aad32d4a5f031b48
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09156798B2
反応ノート
読み込み中…