Acetic Acid → 6-nitro-1H-indole-3-carbaldehyde

HRID 1749748

反応式

HRID 1749748 の反応式
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:13](O)(=[O:15])C.C1N2CN3CN(C2)CN1C3>O>[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([C:8]([CH:13]=[O:15])=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 4101HexamethylenetetramineHCID 785026-Nitro-1H-indole

生成物 1

HCID 52100766-nitro-1H-indole-3-carbaldehyde収率 77%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
120 °C

実験手順

6-Nitroindole (1.0 g, 6.2 mmol) was successively added with acetic acid (2.5 mL), water (5.0 mL), and hexamethylenetetramine (1.2 g, 8.4 mmol), and then the mixture was stirred overnight at 120° C. in a sealed tube. The reaction mixture was added with water, and the precipitated solid was collected by filtration, and then dried to obtain 6-nitro-1H-indole-3-carboxaldehyde (0.91 g, 77%).

後処理

  1. filtrationthe precipitated solid was collected by filtration
  2. customdried

出典と根拠

ORDレコード
ord-716b45a55ff14e2fafb06dc475b3bfe6
出典データセット
uspto-grants-2015_10
特許番号
US09156827B2

関連ノート

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