Acetic Acid → 6-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
反応式
[Br:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1.[C:11](O)(=[O:13])C.C1N2CN3CN(C2)CN1C3>O>[Br:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[C:10]([CH:11]=[O:13])[C:5]2=[CH:4][CH:3]=1参加物
5
反応条件
- 温度
- 120 °C
実験手順
6-Bromo-1H-pyrrolo[2,3-b]pyridine (0.028 g, 0.14 mmol) was successively added with acetic acid (0.1 mL), water (0.2 mL), and hexamethylenetetramine (0.028 g, 0.20 mmol), and then the mixture was stirred overnight at 120° C. in a sealed tube. The reaction mixture was added with water, and the precipitated solid was collected by filtration to obtain 6-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (0.008 g, 25%).
後処理
- filtrationthe precipitated solid was collected by filtration
出典と根拠
- ORDレコード
- ord-54e04f4ed5f144b7826a660df3b6b91a
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09156827B2
反応ノート
読み込み中…