Acetic Acid → 6-Methyl-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde

HRID 1749811ノート

反応式

HRID 1749811 の反応式
[CH3:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1.[C:11](O)(=[O:13])C.C1N2CN3CN(C2)CN1C3>O>[CH3:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[C:10]([CH:11]=[O:13])[C:5]2=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 4101HexamethylenetetramineHCID 114577166-Methyl-1H-pyrrolo[2,3-b]pyridine

生成物 1

HCID 247295536-Methyl-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde収率 67%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
120 °C

実験手順

6-Methyl-1H-pyrrolo[2,3-b]pyridine (0.066 g, 0.50 mmol) was successively added with acetic acid (0.2 mL), water (0.4 mL), and hexamethylenetetramine (0.098 g, 0.70 mmol), and then the mixture was stirred overnight at 120° C. in a sealed tube. The reaction mixture was added with water, and then the precipitated solid was collected by filtration to obtain 6-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (0.054 g, 67%).

後処理

  1. filtrationthe precipitated solid was collected by filtration

出典と根拠

ORDレコード
ord-c33c572ec4ca43839d20afa4e0002597
出典データセット
uspto-grants-2015_10
特許番号
US09156827B2

反応ノート

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