Benzoyl Peroxide → 7-bromomethylbenzofuran-3(2H)-one
反応式
[CH3:1][C:2]1[C:10]2[O:9][CH2:8][C:7](=[O:11])[C:6]=2[CH:5]=[CH:4][CH:3]=1.[Br:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:12][CH2:1][C:2]1[C:10]2[O:9][CH2:8][C:7](=[O:11])[C:6]=2[CH:5]=[CH:4][CH:3]=1参加物
5
実験手順
A solution of 7-methylbenzofuran-3(2H)-one (0.759 g, 5.12 mol) in carbon tetrachloride (50 mL) was added with N-bromosuccinimide (1.00 g, 5.63 mmol) and benzoyl peroxide (0.0830 g, 0.256 mmol), and the mixture was refluxed for 4 hours by heating. The reaction mixture was cooled to room temperature, and then filtered, and the resulting filtrate was concentrated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain 7-bromomethylbenzofuran-3(2H)-one (0.573 g, 49%).
後処理
- temperaturethe mixture was refluxed for 4 hours
- temperatureby heating
- filtrationfiltered
- concentrationthe resulting filtrate was concentrated
- customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate)
出典と根拠
- ORDレコード
- ord-40be46b5db76468cbe5a7fcd105a96c3
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09156827B2
反応ノート
読み込み中…