Iodine → HCID 178418276、化合物

反応式

[Mg:1].II.[Br:4]CCBr.Br[C:9]1[CH:14]=CC(OC)=[CH:11][CH:10]=1.[CH2:17]1[CH2:21][O:20][CH2:19][CH2:18]1>>[CH2:11]([Mg:1][Br:4])[C:10]1[CH:18]=[CH:17][C:21]([O:20][CH3:19])=[CH:14][CH:9]=1

参加物

反応物 5

HCID 807Iodine

HCID 77304-Bromoanisole

HCID 78391,2-Dibromoethane

HCID 8028Tetrahydrofuran

HCID 5462224Magnesium

生成物 1

HCID 178418276HCID 178418276、化合物

反応条件

温度: 20 °C

実験手順

Magnesium (36 g, 1.5 mol), iodine (a few crystals) and THF (1 L) were heated under nitrogen, with stirring, at reflux for 15 min. The mixture was cooled to 20° C., stirring stopped, and 1,2-dibromoethane (2.5 ml) added. After an exothermic reaction was observed (a few min) stirring was restarted which was accompanied by a rise in temperature to 35° C. The mixture was cooled to 20° C. and 4-bromoanisole slowly added over 1 h at 14°-18° C. with cooling. Stirring was continued for 10 min after the addition was complete.