7-(4-(benzyloxy)butoxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one → 7-(4-Hydroxybutoxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
反応式
C([O:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[N:23]=[C:22]2[C:17]([CH2:18][CH2:19][C:20](=[O:24])[NH:21]2)=[CH:16][CH:15]=1)C1C=CC=CC=1>CCO.[Pd]>[OH:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[N:23]=[C:22]2[C:17]([CH2:18][CH2:19][C:20](=[O:24])[NH:21]2)=[CH:16][CH:15]=1参加物
4
実験手順
To the solution of intermediate 10 (900 mg, 2.8 mmol) in EtOH (25 mL) was added 10% Pd/C (400 mg) under an atmosphere of H2 overnight. The reaction was filtered to remove the Pd/C and the filtrate was concentrated and washed with Et2O to give 7-(4-hydroxybutoxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one (intermediate 11) (360 mg, 55%) as a white solid.
後処理
- filtrationThe reaction was filtered
- customto remove the Pd/C
- concentrationthe filtrate was concentrated
- washwashed with Et2O
出典と根拠
- ORDレコード
- ord-18ab8a7b8833454aade4c26209ca03e5
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09156822B2
反応ノート
読み込み中…