HCID 86714409、化合物 → HCID 86714410、化合物
反応式
[C:1]([O:5][C:6](=[O:30])[C@@H:7]([NH:12][C:13](=[O:29])[C:14]1[CH:19]=[CH:18][C:17]([NH:20][CH:21]([CH2:24][CH3:25])[CH2:22][CH3:23])=[C:16]([N+:26]([O-])=O)[CH:15]=1)[CH2:8][CH:9]([CH3:11])[CH3:10])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:30])[C@@H:7]([NH:12][C:13](=[O:29])[C:14]1[CH:19]=[CH:18][C:17]([NH:20][CH:21]([CH2:24][CH3:25])[CH2:22][CH3:23])=[C:16]([NH2:26])[CH:15]=1)[CH2:8][CH:9]([CH3:10])[CH3:11])([CH3:2])([CH3:3])[CH3:4]参加物
4
実験手順
11.5 g of (S)-2-[4-(1-ethyl-propylamino)-3-nitro-benzoylamino]-4-methyl-pentanoic acid tert-butyl ester were dissolved in 100 ml ethanol, 1.0 g of palladium on carbon (10%) were added and the mixture was hydrogenated at 5 bar for 4 h. the catalyst was removed by filtration over celite, and the reaction mixture was concentrated and purified by chromatography (silica, heptane/ethyl acetate) to yield 6.5 g (61%) of (S)-2-[3-amino-4-(1-ethyl-propylamino)-benzoylamino]-4-methyl-pentanoic acid tert-butyl ester as a colourless oil.