3-Nitro-4-(2-trifluoromethyl-cyclohexylamino)-benzoic acid methyl ester → HCID 86714449、化合物

HRID 1750241ノート

反応式

HRID 1750241 の反応式
[CH3:1][O:2][C:3](=[O:24])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]2[C:17]([F:20])([F:19])[F:18])=[C:6]([N+:21]([O-])=O)[CH:5]=1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:24])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]2[C:17]([F:20])([F:18])[F:19])=[C:6]([NH2:21])[CH:5]=1

参加物

4

反応物 1

HCID 867144483-Nitro-4-(2-trifluoromethyl-cyclohexylamino)-benzoic acid methyl ester

生成物 1

HCID 86714449HCID 86714449、化合物収率 97%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

1.63 g 3-Nitro-4-(2-trifluoromethyl-cyclohexylamino)-benzoic acid methyl ester were dissolved in 25 ml methanol, 0.03 g of palladium on carbon (10%) were added and the mixture was hydrogenated at 5 bar for 16 h. The catalyst was removed by filtration over celite, the filtrate was concentrated to obtain 1.44 g (97%) of 3-Amino-4-(2-trifluoromethyl-cyclohexylamino)-benzoic acid methyl ester.

後処理

  1. customThe catalyst was removed by filtration over celite
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-eec625b33519442c8f260dde60b5deb7
出典データセット
uspto-grants-2015_10
特許番号
US09156796B2

反応ノート

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