N-Iodosuccinimide → 4-Chloro-5-iodo-2-methyl-7H-pyrrolo(2,3-d)pyrimidine

HRID 1750286ノート

反応式

HRID 1750286 の反応式
[Cl:1][C:2]1[C:3]2[CH:11]=[CH:10][NH:9][C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1.[I:12]N1C(=O)CCC1=O>ClCCl>[Cl:1][C:2]1[C:3]2[C:11]([I:12])=[CH:10][NH:9][C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1

参加物

4

反応物 2

HCID 120273N-IodosuccinimideHCID 109208984-CHLORO-2-METHYL-7H-PYRROLO[2,3-D]PYRIMIDINE

生成物 1

HCID 665707094-Chloro-5-iodo-2-methyl-7H-pyrrolo(2,3-d)pyrimidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (400 mg, 2.4 mmol) in dichloromethane (10 mL) was added N-iodosuccinimide (537 mg, 2.39 mmol). The mixture was stirred at room temperature for 2 hours, then washed with aqueous sodium sulfite solution, dried over sodium sulfate, filtered, and concentrated in vacuo to provide the product as a brown solid. Yield: 330 mg, 1.12 mmol, 47%. LCMS m/z 293.8[M+H+].

後処理

  1. washwashed with aqueous sodium sulfite solution
  2. dry with materialdried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-74f17f59bafd4ada96f0342e0110db1f
出典データセット
uspto-grants-2015_10
特許番号
US09156845B2

反応ノート

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