Hydrochloric Acid → 4-Dibenzofuranamine
反応式
[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[C:4]([NH:14]C(=O)C)=[CH:3][CH:2]=1.Cl.C(=O)([O-])[O-].[Na+].[Na+]>CO>[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[C:4]([NH2:14])=[CH:3][CH:2]=1参加物
5
実験手順
N-(dibenzo[b,d]furan-4-yl)acetamide (90 g, 400 mmol) was suspended in the mixture of concentrated HCl (240 mL) and methanol (240 mL). The reaction was refluxed for 2 h and then cooled to room temperature. Saturated sodium carbonate was used to neutralize the solution. The residue was collected by filtration and redissolved in DCM. After dried over sodium sulfate, the solution was concentrated to give dibenzo[b,d]furan-4-amine (67 g, 92% yield) as brown solid.
後処理
- temperatureThe reaction was refluxed for 2 h
- filtrationThe residue was collected by filtration
- dissolutionredissolved in DCM
- dry with materialAfter dried over sodium sulfate
- concentrationthe solution was concentrated
出典と根拠
- ORDレコード
- ord-3da70b8dfe19424388ff7ae00b6e089f
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09156870B2
反応ノート
読み込み中…