4-Bromophenacyl bromide → HCID 69673289、化合物

HRID 1751335ノート

反応式

HRID 1751335 の反応式
[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][C@H:9]1[C:17]([OH:19])=[O:18])=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[CH2:21][C:22]([C:24]1[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][CH:25]=1)=[O:23].CCN(CC)CC>CC#N.CCOC(C)=O.C([O-])(O)=O.[Na+].[Cl-].[Na+].O>[N:8]1([C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][C@H:9]1[C:17]([O:19][CH2:21][C:22]([C:24]1[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][CH:25]=1)=[O:23])=[O:18]

参加物

8

反応物 3

HCID 74544-Bromophenacyl bromideHCID 8471TriethylamineHCID 2755955(2S)-1-(tert-Butoxycarbonyl)-2,3-dihydro-1H-indole-2-carboxylic acid

生成物 1

HCID 69673289HCID 69673289、化合物

試薬・触媒・溶媒 4

HCID 6342Acetonitrile溶媒HCID 8857Ethyl Acetate溶媒HCID 516892Sodium Bicarbonate溶媒HCID 57417360Sodium chloride; water溶媒

反応条件

温度
55 °C

実験手順

To a solution of (S)-1-(tert-butoxycarbonyl)indoline-2-carboxylic acid (1.61 g, 6.11 mmol) and 2-bromo-1-(4-bromophenyl)ethanone (2.55 g, 9.17 mmol) in MeCN (25 mL) was added Et3N (1.27 mL, 9.17 mmol). The solution was heated to 55° C. and stirred o/n. The solution was cooled to rt, diluted with EtOAc, sat. NaHCO3, brine, dried with MgSO4, and concentrated. The residue was taken onto the next step crude.

後処理

  1. temperatureThe solution was cooled to rt
  2. dry with materialdried with MgSO4
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-066fd6372ed14d02b08e01ff46a81305
出典データセット
uspto-grants-2015_10
特許番号
US09156823B2

反応ノート

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