1-Butyne → 2-But-1-ynyl-4-fluorophenylamine

HRID 1751794ノート

反応式

HRID 1751794 の反応式
O1[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:6][C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[C:9](I)[CH:8]=1.C#CCC>[Cu](I)I.C(N(CC)CC)C>[C:2]([C:11]1[CH:12]=[C:7]([F:6])[CH:8]=[CH:9][C:10]=1[NH2:13])#[C:3][CH2:4][CH3:5]

参加物

6

反応物 3

HCID 78461-ButyneHCID 8028TetrahydrofuranHCID 27782834-Fluoro-2-iodoaniline

生成物 1

HCID 580803722-But-1-ynyl-4-fluorophenylamine

試薬・触媒・溶媒 2

HCID 83717Copper iodide触媒HCID 8471Triethylamine溶媒

実験手順

80 ml of tetrahydrofuran is placed under argon. 5 g 4-fluoro-2-iodophenylamine, 0.74 g dichlorobis(triphenylphosphine) palladium(II), 0.2 g copper iodide and 8.8 ml triethylamine are added. 4 g gaseous 1-butyne are passed through the suspension. The reaction mixture is stirred under argon for 15 hours at ambient temperature, then filtered through Celite and evaporated to dryness. 3.4 g product are obtained in the form of a solid. 1H NMR (400 MHz, DMSO): 2.45 (2H, q); 1.18 (3H, t).

後処理

  1. filtrationfiltered through Celite
  2. customevaporated to dryness

出典と根拠

ORDレコード
ord-72be47ac980441c8a82a26bc0fd26d7d
出典データセット
uspto-grants-2015_10
特許番号
US09161927B2

反応ノート

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