Sodium Hydroxide → HCID 89767207、化合物

HRID 1752515ノート

反応式

HRID 1752515 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][C:23]2[S:24][CH:25]=[C:26]([C:28]([O:30]C)=[O:29])[N:27]=2)[CH2:18][CH2:17]1)=[O:13].[OH-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][C:23]2[S:24][CH:25]=[C:26]([C:28]([OH:30])=[O:29])[N:27]=2)[CH2:18][CH2:17]1)=[O:13]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 89767420HCID 89767420、化合物

生成物 1

HCID 89767207HCID 89767207、化合物収率 43%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of compound 7 (1.85 mmoles) in MeOH (10 mL) aqueous 1M NaOH (3.7 mL) was added. The solution was refluxed overnight then the organic solvent was removed under vacuum, the residue was diluted with H2O and the pH was adjusted to 5 by adding 1M HCl. The mixture was kept at 4° C. overnight then the resulting solid was filtered, washed with fresh water and dried under vacuum to give 2-{[4-({[(5-Methoxy-1H-indazol-3-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}-1,3-thiazole-4-carboxylic acid 8 (43% yield).

後処理

  1. temperatureThe solution was refluxed overnight
  2. customthe organic solvent was removed under vacuum
  3. additionthe residue was diluted with H2O
  4. additionby adding 1M HCl
  5. filtrationthe resulting solid was filtered
  6. washwashed with fresh water
  7. customdried under vacuum

出典と根拠

ORDレコード
ord-11444f69f27d4c0ba75d38de67be0217
出典データセット
uspto-grants-2015_10
特許番号
US09163013B2

反応ノート

読み込み中…