Sodium Azide → 1-(Azidomethyl)-4-(trifluoromethyl)benzene

HRID 1752556ノート

反応式

HRID 1752556 の反応式
[N-:1]=[N+:2]=[N-:3].[Na+].[F:5][C:6]([F:16])([F:15])[C:7]1[CH:14]=[CH:13][C:10]([CH2:11]Br)=[CH:9][CH:8]=1>CS(C)=O.C(OCC)(=O)C>[N:1]([CH2:11][C:10]1[CH:9]=[CH:8][C:7]([C:6]([F:5])([F:15])[F:16])=[CH:14][CH:13]=1)=[N+:2]=[N-:3]

参加物

5

反応物 2

HCID 33557Sodium AzideHCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzene

生成物 1

HCID 498459471-(Azidomethyl)-4-(trifluoromethyl)benzene

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Sodium azide (2.30 g, 35.4 mmol) was added to a solution of 4-(trifluoromethyl)benzyl bromide (4.26 g, 17.8 mmol) dissolved in dimethyl sulfoxide (15 mL) and stirred at ambient temperature overnight. The mixture was diluted with ethyl acetate, washed with water and brine, and dried over sodium sulfate. After filtration, the solvent was removed under reduced pressure to afford the title compound. The crude product was used in the next step without further characterization.

後処理

  1. washwashed with water and brine
  2. dry with materialdried over sodium sulfate
  3. filtrationAfter filtration
  4. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-8799b9f656294b06ad3fcd74eccbaab3
出典データセット
uspto-grants-2015_10
特許番号
US09163007B2

反応ノート

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