Hydrochloric Acid → N-(5-Cyano-2-fluoro-4-methoxy-6-methylbiphenyl-3-yl)-2,2-dimethylpropionamide

HRID 17526ノート

反応式

HRID 17526 の反応式
[NH2:1][C:2]1[C:3]([O:18][CH3:19])=[C:4]([C:16]#[N:17])[C:5]([CH3:15])=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:7]=1[F:8].[C:20](Cl)(=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22].Cl>N1C=CC=CC=1>[C:16]([C:4]1[C:3]([O:18][CH3:19])=[C:2]([NH:1][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22])[C:7]([F:8])=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]=1[CH3:15])#[N:17]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 62493Pivaloyl chlorideHCID 860975095-Amino-6-fluoro-4-methoxy-2-methylbiphenyl-3-carbonitrile

生成物 1

HCID 86630868N-(5-Cyano-2-fluoro-4-methoxy-6-methylbiphenyl-3-yl)-2,2-dimethylpropionamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

5-Amino-6-fluoro-4-methoxy-2-methylbiphenyl-3-carbonitrile (I-236) (300 mg, 1.17 mmol) was dissolved in pyridine (3 ml), and under nitrogen atmosphere at 0° C., pivaloyl chloride (433 μl, 3.51 mmol) was dropwise added. After stirring at roam temperature for 20 hours, aqueous 1 M hydrochloric acid solution was added to the reaction liquid at 0° C. The solution was extracted twice with ethyl acetate. The organic layer was washed with saturated brine, then dried over anhydrous sodium sulfate.

後処理

  1. extractionThe solution was extracted twice with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate

出典と根拠

ORDレコード
ord-b7d31a10c76446828935736c15535c06
出典データセット
uspto-grants-2010_06
特許番号
US07737166B2

反応ノート

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