反応式
[F:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][CH2:7][CH2:8][CH2:9][C:10]2[N:14]=[C:13]([NH2:15])[NH:12][N:11]=2)=[CH:4][CH:3]=1.[CH3:18][CH:19]([C:21](=O)[CH2:22][C:23](=O)[CH:24]([CH3:26])[CH3:25])[CH3:20].ClC1C=CC(OCCCC2N=C(N)NN=2)=CC=1.FC1C=CC(O)=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH2:8][CH2:9][C:10]2[N:14]=[C:13]3[N:15]=[C:21]([CH:19]([CH3:20])[CH3:18])[CH:22]=[C:23]([CH:24]([CH3:26])[CH3:25])[N:12]3[N:11]=2)=[CH:16][CH:17]=1.[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH2:8][CH2:9][C:10]2[N:14]=[C:13]([NH2:15])[NH:12][N:11]=2)=[CH:16][CH:17]=1参加物
6
反応物 4
生成物 2
実験手順
The title compound was prepared according to the experimentals described for Example 22 above from 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine and 2,6-dimethyl-3,5-heptanedione in 61% yield. The reagent 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine was prepared by a similar procedure for the synthesis of 3-[3-(4-chlorophenoxy)propyl]-1H-1,2,4-triazol-5-amine in Example 22 above, beginning from 4-fluorophenol instead of 4-chlorophenol. EM (calc.): 356.2; MS (ESI) m/e: 357.4 (M+H)+.
出典と根拠
- ORDレコード
- ord-0e8312fa9e09458bb6dc6af7b540ba54
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09163027B2
関連ノート
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