3-Chloro-2-iodo-5-nitropyridine → 3-Chloro-5-nitropicolinonitrile
反応式
[Cu]([C:4]#[N:5])C#N.[Cl:6][C:7]1[C:8](I)=[N:9][CH:10]=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=1>C(#N)C>[Cl:6][C:7]1[C:8]([C:4]#[N:5])=[N:9][CH:10]=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
A suspension of copper cyanide (7 g) and 3-chloro-2-iodo-5-nitro-pyridine (7 g) in acetonitrile (200 mL) was heated to 80° C. within 1 hour and stirred at 80° C. for 5 hours. The solvent was evaporated and the residue was filtered in ethyl acetate over silicon dioxide gave 3-chloro-2-cyano-5-nitro-pyridine (4.26 g).
後処理
- customThe solvent was evaporated
- filtrationthe residue was filtered in ethyl acetate over silicon dioxide
出典と根拠
- ORDレコード
- ord-425a9c3c12734dd9bc2e4162542bae20
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09162986B2
反応ノート
読み込み中…