Pyridine → 5-Bromo-2-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine

HRID 1752949ノート

反応式

HRID 1752949 の反応式
N1[C:5]([C:6]2[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][N:7]=2)=[N:4][N:3]=N1.N1C=CC=CC=1.[C:19](OCC)(=[O:21])[CH3:20]>C(OC(=O)C)(=O)C>[CH3:20][C:19]1[O:21][C:5]([C:6]2[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][N:7]=2)=[N:4][N:3]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 8857Ethyl AcetateHCID 234386835-Bromo-2-(2H-tetrazol-5-yl)pyridine

生成物 1

HCID 234386435-Bromo-2-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine収率 80%

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

In 130 ml of acetic anhydride was dissolved 8.6 g of 2-(tetrazol-5-yl)-5-bromopyridine prepared in the Preparation example 6. And then the solution was added with 15 ml of pyridine and stirred for 3 hours for reaction. The reaction mixture was added with ethyl acetate and extracted to separate organic layer. And then the organic layer was washed with water and brine. The organic layer was dehydrated, filtrated and concentrated in vacuo to give 7.3 g of the title compound. Yield 80%.

後処理

  1. customprepared in the Preparation example 6
  2. extractionextracted
  3. customto separate organic layer
  4. washAnd then the organic layer was washed with water and brine
  5. filtrationfiltrated
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-922b978cd7784d899d3e8bca634c9442
出典データセット
uspto-grants-2015_10
特許番号
US09163043B2

反応ノート

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