Sodium borohydride → 2-(3-iodo-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-methylpropan-1-ol

HRID 1753069ノート

反応式

HRID 1753069 の反応式
[I:1][C:2]1[C:6]2[CH:7]=[N:8][CH:9]=[CH:10][C:5]=2[N:4]([C:11]([CH3:17])([CH3:16])[C:12](OC)=[O:13])[CH:3]=1.[BH4-].[Na+]>CCO>[I:1][C:2]1[C:6]2[CH:7]=[N:8][CH:9]=[CH:10][C:5]=2[N:4]([C:11]([CH3:17])([CH3:16])[CH2:12][OH:13])[CH:3]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 90094007methyl 2-(3-iodo-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-methylpropanoate

生成物 1

HCID 900938832-(3-iodo-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-methylpropan-1-ol収率 39%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of methyl 2-(3-iodo-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-methylpropanoate (Preparation 67, 10.8 g, 31.38 mmol) in EtOH (100 mL) was added sodium borohydride (2.37 g, 62.8 mmol) and the reaction stirred at room temperature for 5 hours. The reaction was quenched by the addition of water (100 mL) and the phases separated through a phase separation cartridge. The organic layer was concentrated in vacuo to afford and orange oil that was triturated with ether to afford an orange solid as the title compound (3.86 g, 39%).

後処理

  1. customThe reaction was quenched by the addition of water (100 mL)
  2. customthe phases separated through a phase separation cartridge
  3. concentrationThe organic layer was concentrated in vacuo
  4. customto afford
  5. customorange oil that was triturated with ether

出典と根拠

ORDレコード
ord-a8a52fafde3c43c385db4245911574f3
出典データセット
uspto-grants-2015_10
特許番号
US09163021B2

反応ノート

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