Hydrochloric Acid → 1-(2-Chloro-6-hydroxyphenyl)ethan-1-one

HRID 1753965ノート

反応式

HRID 1753965 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8]COC)[C:3]=1[C:12](=[O:14])[CH3:13].Cl>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:12](=[O:14])[CH3:13]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 669605601-[2-Chloro-6-(methoxymethoxy)phenyl]ethanone

生成物 1

HCID 5934151-(2-Chloro-6-hydroxyphenyl)ethan-1-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
65 °C

実験手順

To a solution of 1-(2-chloro-6-(methoxymethoxy)phenyl)ethanone (38 g, 177.03 mmol, 1.00 equiv) in THF (380 mL) was added HCl (aq. 35 g, 2.00 equiv, 36%). The resulting mixture was allowed to react, with stirring, for 3 h at 65° C. The resulting mixture was extracted with ethyl acetate. The organic phase was separated, dried and concentrated under vacuum to give the crude title compound.

後処理

  1. customto react
  2. extractionThe resulting mixture was extracted with ethyl acetate
  3. customThe organic phase was separated
  4. customdried
  5. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-03868c8c1c2a46798ba082f6f08f4fe3
出典データセット
uspto-grants-2015_10
特許番号
US09168248B2

反応ノート

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