Acetyl chloride → (S)-N-(1-(5-Hydroxypyridin-2-yl)ethyl)acetamide

HRID 1754058ノート

反応式

HRID 1754058 の反応式
[NH2:1][C@H:2]([C:4]1[N:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)[CH3:3].[C:11](Cl)(=[O:13])[CH3:12]>C1COCC1>[OH:10][C:7]1[CH:6]=[CH:5][C:4]([C@@H:2]([NH:1][C:11](=[O:13])[CH3:12])[CH3:3])=[N:9][CH:8]=1

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 78960964HCID 78960964、化合物

生成物 1

HCID 86687917(S)-N-(1-(5-Hydroxypyridin-2-yl)ethyl)acetamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To 1.00 g (5.73 mmol) (S)-6-(1-aminoethyl)pyridin-3-ol in 10 ml THF and 3.99 mL TEA (28.6 mmol) are slowly added 494 mg (6.30 mmol) acetyl chloride and stirring is continued for 2 h. The reaction is quenched by the addition of water and extracted several times with DCM. The org. layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, DCM/MeOH/NH3 90/9/1).

後処理

  1. customThe reaction is quenched by the addition of water
  2. extractionextracted several times with DCM
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customthe solvent is removed in vacuo
  6. customThe crude product is purified by column chromatography (silica gel, DCM/MeOH/NH3 90/9/1)

出典と根拠

ORDレコード
ord-5b00ee20e45e4233b178b1bc903bf176
出典データセット
uspto-grants-2015_10
特許番号
US09169205B2

反応ノート

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