Sodium Hydroxide → 4-(4-Methoxyphenyl)sulfonylaniline

HRID 1754109ノート

反応式

HRID 1754109 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([C:12]2[CH:17]=[CH:16][C:15]([NH:18]C(=O)C)=[CH:14][CH:13]=2)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[OH-].[Na+]>CCO>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([S:9]([C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)(=[O:10])=[O:11])=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 70978553N-(4-((4-methoxyphenyl)sulfonyl)phenyl)acetamide

生成物 1

HCID 5166674-(4-Methoxyphenyl)sulfonylaniline

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

To a solution of N-(4-((4-methoxyphenyl)sulfonyl)phenyl)acetamide (111 mg, 0.36 mmol) in EtOH (8 mL) is added NaOH (10 M in water, 0.6 mL, 6 mmol). The mixture is heated at 80° C. for 4 h and the solvent is evaporated. The residue is partitioned between EtOAc (15 mL) and brine (10 mL) and the layers are separated. The aqueous layer is extracted with EtOAc (10 mL) and the combined extracts are dried (Na2SO4) and evaporated. The white solid obtained (76 mg, 80%) is used to the next step without further purification.

後処理

  1. customthe solvent is evaporated
  2. customThe residue is partitioned between EtOAc (15 mL) and brine (10 mL)
  3. customthe layers are separated
  4. extractionThe aqueous layer is extracted with EtOAc (10 mL)
  5. dry with materialthe combined extracts are dried (Na2SO4)
  6. customevaporated
  7. customThe white solid obtained (76 mg, 80%)
  8. customis used to the next step without further purification

出典と根拠

ORDレコード
ord-c9df4bdace9147c9b87ab9e07438a8dd
出典データセット
uspto-grants-2015_10
特許番号
US09169209B2

反応ノート

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