HCID 86257708、化合物 → 1-(4-fluorophenyl)-1H-pyrazol-4-amine
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([N+:13]([O-])=O)[CH:10]=[N:9]2)=[CH:4][CH:3]=1>CCO.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([NH2:13])[CH:10]=[N:9]2)=[CH:6][CH:7]=1参加物
4
実験手順
A mixture of 1-(4-fluorophenyl)-4-nitropyrazole (0.820 g, 3.96 mmol) and 10% Pd/C (0.133 g, 50% wet by wt) in EtOH (50 mL) was fitted onto a Parr apparatus and agitated under H2 at 40 psi for 40 min. The reaction mixture was then filtered through filter paper. The filtrate was collected and concentrated in vacuo to give 1-(4-fluorophenyl)pyrazol-4-amine as an oil (0.675 g, 96%).
後処理
- customwas fitted onto a Parr apparatus
- filtrationThe reaction mixture was then filtered
- filtrationthrough filter paper
- customThe filtrate was collected
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-a18390c029154e59af9a3eb968c86735
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09169248B2
反応ノート
読み込み中…