Sodium Hydroxide → 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-2-Methyl-

HRID 1754494ノート

反応式

HRID 1754494 の反応式
COC([N:5]1[C:9]2=[N:10][C:11]([Cl:14])=[CH:12][CH:13]=[C:8]2[CH:7]=[C:6]1[CH3:15])=O.[OH-].[Na+]>CO>[Cl:14][C:11]1[N:10]=[C:9]2[NH:5][C:6]([CH3:15])=[CH:7][C:8]2=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 73013581HCID 73013581、化合物

生成物 1

HCID 210617341H-Pyrrolo[2,3-b]pyridine, 6-chloro-2-Methyl-

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

6-Chloro-2-methyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid methyl ester (0.225 g, 1 mmol) is dissolved in methanol (30 ml) and 1M NaOH (10 ml) and stirred at room temperature overnight. The methanol is removed in vacuo and the resulting white suspension is extracted with chloroform (3×20 ml), dried (MgS04) and concentrated in vacuo to yield a white powder which is dried under high vacuum to yield the titled product. (MH+167).

後処理

  1. customThe methanol is removed in vacuo
  2. extractionthe resulting white suspension is extracted with chloroform (3×20 ml)
  3. customdried (MgS04)
  4. concentrationconcentrated in vacuo
  5. customto yield a white powder which
  6. customis dried under high vacuum

出典と根拠

ORDレコード
ord-60d331f27706454cbd8ee037714249b7
出典データセット
uspto-grants-2015_10
特許番号
US09169251B2

反応ノート

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