Acetic Anhydride → N-(4-Fluoro-2-methylphenyl)acetamide

HRID 17546

反応式

HRID 17546 の反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[C:11]([CH3:16])[CH:10]=1>C(Cl)(Cl)Cl>[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:5](=[O:7])[CH3:6])=[C:11]([CH3:16])[CH:10]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 679824-Fluoro-2-methylaniline

生成物 1

HCID 2737623N-(4-Fluoro-2-methylphenyl)acetamide収率 99.8%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Acetic anhydride (17.7 ml, 0.19 mol) was dropwise added to 4-fluoro-2-methylaniline (234 g, 0.19 mol). The solidified reaction mixture was dissolved in chloroform, washed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine, then dried over anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the residue was dried with a vacuum pump to obtain the entitled compound (31.7 g, 99%) as a pale red solid.

後処理

  1. customThe solidified reaction mixture
  2. washwashed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated away under reduced pressure
  5. customthe residue was dried with a vacuum pump

出典と根拠

ORDレコード
ord-b28a3fb55f434213817c419a6f86b40a
出典データセット
uspto-grants-2010_06
特許番号
US07737166B2

関連ノート

読み込み中…