Acetic Anhydride → N-(4-Fluoro-2-methylphenyl)acetamide
反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[C:11]([CH3:16])[CH:10]=1>C(Cl)(Cl)Cl>[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:5](=[O:7])[CH3:6])=[C:11]([CH3:16])[CH:10]=1参加物
4
実験手順
Acetic anhydride (17.7 ml, 0.19 mol) was dropwise added to 4-fluoro-2-methylaniline (234 g, 0.19 mol). The solidified reaction mixture was dissolved in chloroform, washed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine, then dried over anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the residue was dried with a vacuum pump to obtain the entitled compound (31.7 g, 99%) as a pale red solid.
後処理
- customThe solidified reaction mixture
- washwashed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was evaporated away under reduced pressure
- customthe residue was dried with a vacuum pump
出典と根拠
- ORDレコード
- ord-b28a3fb55f434213817c419a6f86b40a
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07737166B2
反応ノート
読み込み中…