Nitric Acid → N-(4-fluoro-2-methyl-6-nitrophenyl)acetamide
反応式
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:15])[CH3:14])=[C:8]([CH3:16])[CH:7]=1>C(O)(=O)C>[F:5][C:6]1[CH:11]=[C:10]([N+:1]([O-:4])=[O:2])[C:9]([NH:12][C:13](=[O:15])[CH3:14])=[C:8]([CH3:16])[CH:7]=1参加物
4
実験手順
With cooling with ice, fuming nitric acid (25 ml) was dropwise added to an acetic acid (100 ml) solution of N-(4-fluoro-2-methylphenyl)acetamide (I-259) (10.0 g, 59.8 mmol), taking 50 minutes. After the addition, then restoration to room temperature and stirring for 23 hours, the reaction liquid was poured into ice. The precipitated solid was collected by filtration, washed with water, then dried to obtain the entitled compound (11.1 g, 87%) as a pale brown solid.
後処理
- additionAfter the addition
- customthe reaction liquid
- additionwas poured into ice
- filtrationThe precipitated solid was collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-c0b4e5a56fc740aabdc16f007c2e158d
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07737166B2
反応ノート
読み込み中…