Nitric Acid → N-(4-fluoro-2-methyl-6-nitrophenyl)acetamide

HRID 17547

反応式

HRID 17547 の反応式
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:15])[CH3:14])=[C:8]([CH3:16])[CH:7]=1>C(O)(=O)C>[F:5][C:6]1[CH:11]=[C:10]([N+:1]([O-:4])=[O:2])[C:9]([NH:12][C:13](=[O:15])[CH3:14])=[C:8]([CH3:16])[CH:7]=1

参加物

4

反応物 2

HCID 944Nitric AcidHCID 2737623N-(4-Fluoro-2-methylphenyl)acetamide

生成物 1

HCID 54330341N-(4-fluoro-2-methyl-6-nitrophenyl)acetamide収率 87%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

With cooling with ice, fuming nitric acid (25 ml) was dropwise added to an acetic acid (100 ml) solution of N-(4-fluoro-2-methylphenyl)acetamide (I-259) (10.0 g, 59.8 mmol), taking 50 minutes. After the addition, then restoration to room temperature and stirring for 23 hours, the reaction liquid was poured into ice. The precipitated solid was collected by filtration, washed with water, then dried to obtain the entitled compound (11.1 g, 87%) as a pale brown solid.

後処理

  1. additionAfter the addition
  2. customthe reaction liquid
  3. additionwas poured into ice
  4. filtrationThe precipitated solid was collected by filtration
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-c0b4e5a56fc740aabdc16f007c2e158d
出典データセット
uspto-grants-2010_06
特許番号
US07737166B2

関連ノート

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