Dimethylformamide → 6-Amino-3-bromo-4-fluoro-2-methylbenzonitrile
反応式
[Br:1]N1C(=O)CCC1=O.CN(C)C=O.[NH2:14][C:15]1[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([CH3:24])[C:16]=1[C:17]#[N:18]>O>[NH2:14][C:15]1[C:16]([C:17]#[N:18])=[C:19]([CH3:24])[C:20]([Br:1])=[C:21]([F:23])[CH:22]=1参加物
5
実験手順
N-Bromosuccinimide (16.6 g, 93.3 mmol) was gradually added to an N,N-dimethylformamide (250 ml) solution of 2-amino-4-fluoro-6-methylbenzonitrile (I-264) (14.0 g, 93.3 mmol). After stirring for 6 hours, the reaction liquid was poured into water with ice (750 ml), the precipitated solid was collected by filtration. The solid was washed with water, then dried to obtain the entitled compound (20.2 g, 95%) as a gray solid.
後処理
- customthe reaction liquid
- filtrationthe precipitated solid was collected by filtration
- washThe solid was washed with water
- customdried
出典と根拠
- ORDレコード
- ord-dc698879c22a4075bb6d951fdb6285db
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07737166B2
反応ノート
読み込み中…