Sodium Hydroxide → 1-(3,4-difluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid
反応式
[F:1][C:2]1[CH:3]=[C:4]([N:9]2[CH:13]=[N:12][C:11]([C:14]([O:16]CC)=[O:15])=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8].[OH-].[Na+]>CCO.O>[F:1][C:2]1[CH:3]=[C:4]([N:9]2[CH:13]=[N:12][C:11]([C:14]([OH:16])=[O:15])=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of ethyl 1-(3,4-difluorophenyl)-1H-1,2,4-triazole-3-carboxylate (0.30 g, 1.2 mmol, 1 eq) in 5 mL of EtOH/H2O (1.5:1) was added NaOH (0.095 g, 2.4 mmol, 2 eq). The reaction mixture was heated at 50° C. for 1 h then quenched with 0.20 mL of cone. HCl. The contents were filtered and washed with EtOAc then with MeOH and the MeOH filtrate was dried with Na2SO4 and concentrated in vacuo to afford 1-(3,4-difluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid (0.22 g, 0.98 mmol, 84%).