2-Methylpiperidine → 6-(2-Methylpiperidin-1-yl)pyridin-2-amine
反応式
F[C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][CH:3]=1.[CH3:9][CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][NH:11]1>O>[CH3:9][CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][N:11]1[C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 205 °C
実験手順
A suspension of 6-fluoropyridin-2-amine (448 mg, 4 mmol) and 2-methylpiperidine (596 mg, 6 mmol) in water (0.5 mL) was heated to 205° C. in a microwave oven for 30 minutes. The reaction mixture was purified by chromatography (silica gel, 200-300 mesh, petroleum ether:ethyl acetate=10:1) to give 6-(2-methylpiperidin-1-yl)pyridin-2-amine (376 mg, 49%) as a brown oil. LC-MS: [M+H]+, 192.2, tR=1.266 min.
後処理
- customThe reaction mixture was purified by chromatography (silica gel, 200-300 mesh, petroleum ether:ethyl acetate=10:1)
出典と根拠
- ORDレコード
- ord-b7d9946934364018b9a2d316b5fd87c5
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09169259B2
反応ノート
読み込み中…