Allyl bromide → N-allyl-D-alanine t-butyl ester
反応式
[C:1]([O:5][C:6](=[O:10])[C@@H:7]([CH3:9])[NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH2:11](Br)[CH:12]=[CH2:13].C(N(CC)CC)C>C1(C)C=CC=CC=1>[C:1]([O:5][C:6](=[O:10])[C@@H:7]([CH3:9])[NH:8][CH2:13][CH:12]=[CH2:11])([CH3:4])([CH3:3])[CH3:2]参加物
5
実験手順
D-Alanine t-butylester (68) is treated with one equivalent allyl bromide and one equivalent of triethylamine in toluene under reflux. The solvent is evaporated and the product is purified by flash chromatography on silica gel to give (69).
後処理
- temperatureunder reflux
- customThe solvent is evaporated
- customthe product is purified by flash chromatography on silica gel
出典と根拠
- ORDレコード
- ord-48efffad11d94dafa55ea06d132ab9b7
- 出典データセット
- uspto-grants-1995_08
- 特許番号
- US05438118
反応ノート
読み込み中…