Tetramethyl pyrazine-2,3,5,6-tetracarboxylate → 2,3,5,6-Tetramethoxycarbonylpiperazine

HRID 1755963ノート

反応式

HRID 1755963 の反応式
[CH3:1][O:2][C:3]([C:5]1[N:10]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[C:8]([C:15]([O:17][CH3:18])=[O:16])=[N:7][C:6]=1[C:19]([O:21][CH3:22])=[O:20])=[O:4]>C(O)C.[Pd]>[CH3:1][O:2][C:3]([CH:5]1[CH:6]([C:19]([O:21][CH3:22])=[O:20])[NH:7][CH:8]([C:15]([O:17][CH3:18])=[O:16])[CH:9]([C:11]([O:13][CH3:14])=[O:12])[NH:10]1)=[O:4]

参加物

4

反応物 1

HCID 291621Tetramethyl pyrazine-2,3,5,6-tetracarboxylate

生成物 1

HCID 233626442,3,5,6-Tetramethoxycarbonylpiperazine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of tetrakis-methoxycarbonylpyrazine (5.3 g, 16.9 mmol) (prepared in accordance with J. Org. Chem. 37 (19), p2963 (1972)) in 800 ml of dry ethanol, was hydrogenated at 50 bar in the presence of 10 g 5% palladium on charcoal at 80° C. for 16 hours. After cooling, the solution was filtered and evaporated to give slightly yellow crystals. Yield: 4.8 g (90%) , mp. 162°-163° C. (Lit. 162°-163° C.). NMR confirmed the structure.

後処理

  1. temperatureAfter cooling
  2. filtrationthe solution was filtered
  3. customevaporated
  4. customto give slightly yellow crystals
  5. customYield: 4.8 g (90%) , mp. 162°-163° C. (Lit. 162°-163° C.)

出典と根拠

ORDレコード
ord-99063e4947ee44f7af615ba019cf99fc
出典データセット
uspto-grants-1995_08
特許番号
US05439668

反応ノート

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