2-Chloroacetophenone → 2,3-Dimethyl-7-phenacylpyrrolo[2,3-b]pyridine
反応式
[CH3:1][C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11].[CH2:12](Cl)[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:14]>CC#N>[CH3:1][C:2]1[N:10]=[C:5]2[N:6]([CH2:12][C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[O:14])[CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11]参加物
4
実験手順
A solution of 2,3-dimethylpyrrolo[2,3-b]pyridine (146 mg, 1 mmol) and phenacyl chloride (170 mg, 1.1 mmol) in 3 ml CH3CN was refluxed for 4.5 h. The mixture was allowed to cool and the precipitated product filtered off and washed with a small volume of ice cold CCl4 affording 207 mg (69%) pure title compound as the hydrochloride salt.
後処理
- temperatureto cool
- filtrationthe precipitated product filtered off
- washwashed with a small volume of ice cold CCl4 affording 207 mg (69%) pure title compound as the hydrochloride salt
出典と根拠
- ORDレコード
- ord-94867da8d84b4f77b6b178a7617a42b4
- 出典データセット
- uspto-grants-1995_08
- 特許番号
- US05439917
反応ノート
読み込み中…