2-Chloroacetophenone → 3Chloro-2-methyl-7-phenacylpyrrolo-[2,3-b]pyridinehydrochloride
反応式
[Cl:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[CH3:11].Cl[CH2:13][C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:15]>CC#N>[ClH:1].[Cl:1][C:2]1[C:10]2[C:5]([N:6]([CH2:13][C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[O:15])[CH:7]=[CH:8][CH:9]=2)=[N:4][C:3]=1[CH3:11]参加物
4
実験手順
A solution of 200 mg (1.2 mmol) of 3-chloro-2-methyl pyrrolo-[2,3-b]pyridine and 204 mg (1,3 mmol) of 2-chloroacetophenon in 10 ml of CH3CN was refluxed for 48 h. The reaction mixture was cooled to room temperature and stirred for one hour. The precipitate was filtered off to give 260 mg (67%) of 3chloro-2-methyl-7-phenacylpyrrolo-[2,3-b]pyridinehydrochloride.
後処理
- filtrationThe precipitate was filtered off
出典と根拠
- ORDレコード
- ord-e4bc02c4e71b48c0b008201024215e37
- 出典データセット
- uspto-grants-1995_08
- 特許番号
- US05439917
反応ノート
読み込み中…