2-Chloro-4'-fluoroacetophenone → HCID 23207150、化合物

HRID 1756078ノート

反応式

HRID 1756078 の反応式
[C:1]([CH2:3][C:4]1[C:12]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[NH:6][C:5]=1[CH3:13])#[N:2].[F:14][C:15]1[CH:24]=[CH:23][C:18]([C:19](=[O:22])[CH2:20][Cl:21])=[CH:17][CH:16]=1>C(#N)C>[ClH:21].[C:1]([CH2:3][C:4]1[C:12]2[C:7]([N:8]([CH2:20][C:19]([C:18]3[CH:23]=[CH:24][C:15]([F:14])=[CH:16][CH:17]=3)=[O:22])[CH:9]=[CH:10][CH:11]=2)=[N:6][C:5]=1[CH3:13])#[N:2]

参加物

4

反応物 2

HCID 1202482-Chloro-4'-fluoroacetophenoneHCID 19916764(2-Methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetonitrile

生成物 1

HCID 23207150HCID 23207150、化合物収率 55%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of 7 5 mg (0.44 mmol) of 3-cyanomethyl-2-methyl-pyrrolo [2,3 -b]pyridine and 99 mg(0.57 mmol) of 4-fluorophenacyl chloride in 1 ml acetonitrile was refluxed for 48 h. The solvent was evaporated and the residue was treated with 0.4 ml acetonitrile. After filtration the solid was treated with 0,3 ml methanol and 0,4 ml acetonitrile to give 75 mg (55% ) of the title compound.

後処理

  1. customThe solvent was evaporated
  2. additionthe residue was treated with 0.4 ml acetonitrile
  3. filtrationAfter filtration the solid
  4. additionwas treated with 0,3 ml methanol and 0,4 ml acetonitrile

出典と根拠

ORDレコード
ord-5bc533e53c32447ba8b1bceb44421817
出典データセット
uspto-grants-1995_08
特許番号
US05439917

反応ノート

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