反応式
[CH2:1]([N:3]([CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]2[CH:29]=[CH:28][S:27][CH:26]=2)[CH:20]=1)[CH2:4]/[CH:5]=[CH:6]/[C:7]#[C:8][Si](C)(C)C)[CH3:2].C(OCC)(=O)C.O>CO.O1CCCC1.[F-].[K+]>[CH2:1]([N:3]([CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]2[CH:29]=[CH:28][S:27][CH:26]=2)[CH:20]=1)[CH2:4]/[CH:5]=[CH:6]/[C:7]#[CH:8])[CH3:2]参加物
7
反応物 3
生成物 1
試薬・触媒・溶媒 3
実験手順
2.0 g of the resulting allylamine compound was dissolved in a mixture of methanol (5 ml) and tetrahydrofuran (5 ml), and 10 ml of a saturated aqueous solution of potassium fluoride was added. The mixture was stirred overnight at room temperature, and then ethyl acetate and water were added. The organic layer separated was worked up in a customary manner, and the product was purified by silica gel column chromatography [methylene chloride/methanol=100/1] to give 1.3 g of (E)-N-ethyl-N-(2-penten-4-ynyl)-2-[2-[3-(3-thienyl)phenoxy]ethoxy]ethylamine as a colorless oil.
後処理
- additionwas added
- customThe organic layer separated
- customthe product was purified by silica gel column chromatography [methylene chloride/methanol=100/1]
出典と根拠
- ORDレコード
- ord-d22b8a90a9b6490289afc8a4116b7dcf
- 出典データセット
- uspto-grants-1995_08
- 特許番号
- US05439932
関連ノート
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