Hydrochloric Acid → HCID 19390688、化合物

HRID 1756591ノート

反応式

HRID 1756591 の反応式
[C:1]([C:6]1[CH:7]=[C:8]2[C:20](=[CH:21][CH:22]=1)[N:19]1[C:10](=[N:11][C:12]3[C:17]([C:18]1=[O:23])=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:9]2=[O:24])([O:3]CC)=[O:2].Cl>C[Si](I)(C)C.CCOCC.[OH-].[Na+]>[C:1]([C:6]1[CH:7]=[C:8]2[C:20](=[CH:21][CH:22]=1)[N:19]1[C:10](=[N:11][C:12]3[C:17]([C:18]1=[O:23])=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:9]2=[O:24])([OH:3])=[O:2]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 478657HCID 478657、化合物

生成物 1

HCID 19390688HCID 19390688、化合物

試薬・触媒・溶媒 3

HCID 3283Diethyl Ether溶媒HCID 14798Sodium Hydroxide溶媒HCID 85247Trimethylsilyl iodide溶媒

実験手順

A solution of 8-carboethoxyindolo[2,1-b]quinazoline-6,12-dione (2 mmol, from Example 42) in 3 mL of trimethylsilyl iodide (TMSI) is heated to 100° C. for 4 h. The reaction mixture is cooled to room temperature, diluted with ether, and 3 mL of 0.5N NaOH solution is added. The reaction mixture is acidified with 6N HCl and extracted with chloroform. The chloroform extracts are dried, filtered, and concentrated to give 8-carboxyindolo[2,1-b]quinazoline-6,12-dione.

後処理

  1. additionis added
  2. extractionextracted with chloroform
  3. dry with materialThe chloroform extracts are dried
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-ce1f83515d604c89b694691b2e6445e0
出典データセット
uspto-grants-1995_08
特許番号
US05441955

反応ノート

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