Sodium Hydroxide → HCID 446093、化合物

Methyl 1,3-cyclohexadiene-1-carboxylate (914 mg, 6.62 mmol) was dissolved in methanol (10 ml) and a 2N aqueous sodium hydroxide solution (4 ml) was added thereto and the solution was stirred at room temperature for 1 hour. The reaction mixture was concentrated, made acidic with hydrochloric acid and extracted with ethyl acetate. The ethyl acetate layer was washed with an aqueous saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain 1,3-cyclohexadiene-1-carboxylic acid (761 mg, 92.7%) as white solid. This compound has the following NMR spectrum.

1. concentrationThe reaction mixture was concentrated
2. extractionextracted with ethyl acetate
3. washThe ethyl acetate layer was washed with an aqueous saturated sodium chloride solution
4. dry with materialdried over anhydrous sodium sulfate
5. distillationThe solvent was distilled off under reduced pressure

ORDレコード

ord-2aef6630bce044c7b16759e894024703

出典データセット

uspto-grants-1995_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05442062