4-Nitropyridine-2-carboxylic acid 1-oxide → 4-Aminopicolinic acid
反応式
[C:1]([C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[CH:6][N+:5]=1[O-])([OH:3])=[O:2]>C(O)(=O)C.[Pd]>[C:1]([C:4]1[CH:9]=[C:8]([NH2:10])[CH:7]=[CH:6][N:5]=1)([OH:3])=[O:2]参加物
4
実験手順
A solution of 2-carboxy-4-nitropyridine N-oxide (0.5 g, 27 mmol) (E. Prafft et al., J. Prakt. Chem. 1961, 13, 58) in acetic acid (20 ml) was hydrogenated under pressure (70 psi) in the presence of Pd/C. (10%) (0.25 g) at ambient temperature for 2 hours. The catalyst was removed by filtration, and the filtrate evaporated to give 2-carboxy-4-aminopyridine as an off-white solid which was dried in a dessicator (300 mg, 80%).
後処理
- customThe catalyst was removed by filtration
- customthe filtrate evaporated
出典と根拠
- ORDレコード
- ord-23239d1e19a64d37a243bf24ea2648d3
- 出典データセット
- uspto-grants-1995_08
- 特許番号
- US05444057
反応ノート
読み込み中…