HCID 9980291、化合物 → 1-butyl-2-{2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl-4-ylmethyl}1H-indole-3-carboxylic acid

HRID 1757487ノート

反応式

HRID 1757487 の反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]2[N:16]=[N:17][N:18]([C:20]([CH3:28])([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH3:21])[N:19]=2)=[CH:5][CH:4]=1.[CH2:29]([N:33]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:35]([C:42]([OH:44])=[O:43])=[CH:34]1)[CH2:30][CH2:31][CH3:32]>[Pd]>[CH2:29]([N:33]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:35]([C:42]([OH:44])=[O:43])=[C:34]1[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]2[N:16]=[N:17][N:18]([C:20]([CH3:28])([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH3:21])[N:19]=2)=[CH:5][CH:4]=1)[CH2:30][CH2:31][CH3:32]

参加物

4

反応物 2

HCID 9980291HCID 9980291、化合物HCID 103762901-butylindole-3-carboxylic Acid

生成物 1

HCID 103707811-butyl-2-{2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl-4-ylmethyl}1H-indole-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

reacting the 4-bromomethyl-2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl with 2-transmetalated 1-but-1-yl-1H-indole-3-carboxylic acid in the presence of phosphinated palladium catalyst to give 1-butyl-2-[2'-(2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid; and

出典と根拠

ORDレコード
ord-282f4eb03b0d4d4b8639c9139ccd201c
出典データセット
uspto-grants-1995_08
特許番号
US05446121

反応ノート

読み込み中…