Methyl-3,5-didecoxybenzoate → Benzoic acid, 3,5-bis(decyloxy)-

HRID 1757773ノート

反応式

HRID 1757773 の反応式
C[O:2][C:3](=[O:32])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH:7]=[C:6]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[CH:5]=1>CO.[OH-].[Na+]>[CH2:22]([O:21][C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH:7]=1)[C:3]([OH:32])=[O:2])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31]

参加物

4

反応物 1

HCID 10343663Methyl-3,5-didecoxybenzoate

生成物 1

HCID 10320747Benzoic acid, 3,5-bis(decyloxy)-収率 96.5%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of 6.0 g (0.013 mol) of 3,5-bis(decyloxy)benzoic acid methyl ester in 300 ml of methanol and 40 ml of 1N sodium hydroxide was stirred at reflux for 3.5 hours. The reaction mixture was concentrated under reduced pressure and the residue was acidified with 6N HCl. The product was extracted with ethyl acetate and the dried extract was concentrated under reduced pressure to a yellow solid. Recrystallization from methanol-water gave 5.45 g (94% yield, mp 56°-58°) of 3,5-bis(decyloxy)benzoic acid.

後処理

  1. temperatureat reflux for 3.5 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. extractionThe product was extracted with ethyl acetate
  4. extractionthe dried extract
  5. concentrationwas concentrated under reduced pressure to a yellow solid
  6. customRecrystallization from methanol-water

出典と根拠

ORDレコード
ord-8510f08b129b4e5380a144f7ec0969c3
出典データセット
uspto-grants-1995_08
特許番号
US05446189

反応ノート

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