Ethanol → 4-Ethoxy-6-ethylamino-2-isopropylamino-5-pyrimidinecarbonitrile

HRID 1757905ノート

反応式

HRID 1757905 の反応式
[Na].Cl[C:3]1[C:8]([C:9]#[N:10])=[C:7]([NH:11][CH2:12][CH3:13])[N:6]=[C:5]([NH:14][C:15]([C:18]#N)([CH3:17])C)[N:4]=1.[CH2:20]([OH:22])[CH3:21]>CO>[CH2:20]([O:22][C:3]1[C:8]([C:9]#[N:10])=[C:7]([NH:11][CH2:12][CH3:13])[N:6]=[C:5]([NH:14][CH:15]([CH3:17])[CH3:18])[N:4]=1)[CH3:21]

参加物

5

反応物 3

HCID 702EthanolHCID 5360545Sodium2 回HCID 538166454-Chloro-2-(1-cyano-1-methylethylamino)-6-ethylamino-5-pyrimidinecarbonitrile

生成物 1

HCID 205102004-Ethoxy-6-ethylamino-2-isopropylamino-5-pyrimidinecarbonitrile

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

This compound was prepared in the manner of Example XXXIII, substituting 4-chloro-6-ethylamino-2-isopropylamino-5-pyrimidinecarbonitrile and a solution of sodium in ethanol for 4-chloro-2-(1-cyano-1-methylethylamino)-6-ethylamino-5-pyrimidinecarbonitrile and a solution of sodium in methanol. The reaction product was recrystallized from petroleum ether to give 4-ethoxy-6-ethylamino-2-isopropylamino-5-pyrimidinecarbonitrile; mp, 98°-99°.

後処理

  1. customThis compound was prepared in the manner of Example XXXIII
  2. customThe reaction product was recrystallized from petroleum ether

出典と根拠

ORDレコード
ord-de9539452b9d46e28954cdf59ff79508
出典データセット
uspto-grants-1983_02
特許番号
USRE031136

反応ノート

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