Methylamine → 6-amino-4-methyl-beta-carbolin-3-carboxylic acid N-methylamide

HRID 1757981ノート

反応式

HRID 1757981 の反応式
C(O[C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH3:19])=[CH:15][C:14]([NH2:20])=[CH:13][CH:12]=3)=[O:5])C.[CH3:21][NH2:22]>C(O)CO>[CH3:21][NH:22][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH3:19])=[CH:15][C:14]([NH2:20])=[CH:13][CH:12]=3)=[O:5]

参加物

4

反応物 2

HCID 6329MethylamineHCID 130373386-Amino-4-methyl-beta-carboline-3-carboxylic-acid-ethylester

生成物 1

HCID 130373546-amino-4-methyl-beta-carbolin-3-carboxylic acid N-methylamide

試薬・触媒・溶媒 1

HCID 174Ethylene Glycol溶媒

実験手順

1.81 g of 6-amino-4-methyl-β-carbolin-3-carboxylic acid ethyl ester is suspended in 15 ml of ethylene glycol and, while cooling with ice, methylamine is introduced until saturation point is reached. The mixture is then stirred at room temperature for 16 hours, stirred into 100 ml of ice water and the product is filtered off, dried and recrystallized from ethanol-chloroform. 1.42 g of 6-amino-4-methyl-β-carbolin-3-carboxylic acid N-methylamide of melting point 281°-285° C. is obtained.

後処理

  1. additionis introduced until saturation point
  2. filtrationthe product is filtered off
  3. customdried
  4. customrecrystallized from ethanol-chloroform

出典と根拠

ORDレコード
ord-2369231a889d4ea7a28890ce88c5339e
出典データセット
uspto-grants-1983_02
特許番号
US04371536

反応ノート

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